The mixture of the two drugs cured rats from cocaine addiction. Drug use in most cases leads to the formation of psychic and, in some cases, physical dependency. In particular, opioids, and many other "hard drugs" cause both forms of dependence, cocaine, amphetamines and hallucinogens form only psychologically addicted.
Drug experts have learned to effectively deal with the physical component of addiction, but have difficulty with the neutralization of mental discomfort in case of failure of the drug.
Drug treatment group under the leadership of George Cuba (George Koob) from the Scripps Research Institute in La Jolla (USA) tried to cure rats suffering from cocaine addiction, experimenting with a variety of anti-drug agents.
Cube and his colleagues observed that many negative syndromes associated with cocaine frangible arise due to increased activity of the hormone and dynorphin stress related receptors in the brain of rodents addicts. As the scientists explain, taking cocaine not only causes an increase in activity in the pleasure center of the brain, but also strengthens the cells that produce dynorphin.
This phenomenon is one of the causes of failure of cocaine — a high level of dynorphin in the brain of an addict creates a constant feeling of stress and discomfort, which is suppressed by an additional portion of the drug.
"Our previous studies clearly showed that continuous access to cocaine leads to the suppression of a positive reward system in the center of pleasure, and to start and the subsequent strengthening of the mechanisms of stress," — said one of the band members Sanma Wee (Sunmee Wee) from the Scripps Research Institute.
Drug experts have tried to neutralize the effect of both — the suppression of the pay and high stress activity center — with an unusual combination of drugs acting on different parts of the brain.
The first of these — buprenorphine — blocks the kappa opioid receptor-related work stress center in the brain. This drug is not used in medical practice because of the risk of causing dependence similar to heroin. Cube and his colleagues were able to neutralize this effect by precisely metered dose of the other medication — naltrexone. This means blocks the mu-opioid receptor and is widely used in the treatment of heroin addiction in medical practice.
Researchers tested the mixture of the two drugs on rats suffering from drug addiction. A few days after the start of therapy animals rid of cocaine and became addicted to buprenorphine, which confirmed the efficiency of the method the authors.
However, it is not clear how this medication may affect mental and physical health. On the other hand, other methods to combat cocaine addiction does not exist yet, so this unusual reception may be the subject of clinical trials.