AIDS: is there a cure?

AIDS: is there a cure?  Photo from www.sciencephoto.com

Many bacteria and viruses — infectious agents — quite resistant organisms that are well-kept dry and the humidity, heat and cold. Therefore, the destruction of pathogens associated with the use of very strict measures — chemical or thermal sterilization. When virus or bacteria are found on surgical instruments on hospital walls, in raw foods — such measures are justified. However, if exciter lives in the human body, autoclave or bleach will kill rather more gentle master, than a microbe.

New drugs can stimulate the improvement of the virus

One of the most important discoveries of the last century, medical science is antibiotics. It was, perhaps, the first tools that can deal with the infectious agent is in the human body. However, the success of medicine was not long: Many microorganisms have learned to produce the enzyme beta-lactamase which easily decomposes penicillin and similar drugs. Since then started an arms race, in which physicians are developing new antibiotics, and bacteria — the means of protection against them. In much the same way change and viruses — through mutations, they develop mechanisms for the protection of existing drugs.

Despite the fact that the first data on the AIDS virus were obtained in 80-ies of the last century, one hundred percent effective cure for this virus has not been established, and many immune stimulants only to the development of the disease. This is due to the fact that HIV infects cells of the immune system is embedded and in their genome. So instead of immunity is often activated the process of reproduction of the virus.

Currently used for the treatment of HIV 19 specific antiviral drugs, which are mainly related to three classes — nucleoside and non-nucleoside reverse transcriptase blockers and blockers of HIV protease.

Reverse transcriptase and protease — are enzymes which no virus AIDS was not able to replicate in the human body. Blockers prevent reverse transcriptase enzyme incorporate their genetic material into human cells, and protease blockers do not give a new form of viral particles.

The problem, however, is that during treatment virus AIDS which constantly mutates, acquires new enzymes that "spoil" medicine so that it becomes ineffective (this occurs in the case of nucleoside reverse transcriptase blockers). Furthermore, can be altered and target drugs themselves, whereupon preparation they simply "do not know" (in the case of other drug classes).

Doctors lose "arms race"

Today, all over the world anxiously doctors are seeing an increase resilience of AIDS in relation to existing antiviral drugs. As recently scientists have found, resistance (resistance) occurs in at least 10% of newly diagnosed HIV-positive — that is, in their case, existing treatments are ineffective.

The only way out of this situation, most researchers consider a permanent job on the creation of new drugs that allow "catch up" for the mutations of the AIDS virus. This output is not all appear to be as promising.

Opponents of the widespread use of antiviral drugs in developing countries point out that it will increase the immunity of the virus to drugs, and will encourage people to engage in risky behavior. Others believe that more effective to direct resources to prevent new infections. And while there is this dispute, AIDS is spreading at a rate that can destroy a significant portion of humanity before the experts find a way to stop the epidemic of "plague of XX-XXI century".

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