Japanese researchers have discovered the molecular mechanism of diabetes

Japanese researchers have discovered the molecular mechanism of diabetesJapanese scientists working in the United States of America, find that important molecular mechanism underlying the occurrence of diabetes and cancer.

The study concerned the functions of the protein component of TORC 2.

TORC 2 plays a key role in the activation of the protein Akt, affects how cells respond to insulin. Normally, insulin causes the fat cells and muscle tissue to sugar in the blood. With type 2 diabetes, the body produces enough insulin, but the cellular response to this stuff happens. Akt protein activates the proteins that are responsible for the intake of sugar from the blood, and they rush to the cell membrane. Laboratory rodents lacking the gene Akt, showed signs of diabetes.

Another role of the protein Akt is that it regulates the growth of fetal tissues and can cause the formation of malignant cells.

TORC 2 and its importance in the activation of Akt were already known five years ago. The researchers studied how the body of Akt in yeast. They found the protein Ryh 1, which binds to the substance of guanosine triphosphate and activating complex TORC 2. When one Ryh mutating yeast become more susceptible to stress factors. In humans, there is an analog Ryh 1 — a protein called Rab6. This protein causes other molecules inside a living cell, move and has great significance in the broadcast signals of insulin.

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