In the U.S., will begin testing the vaccine against Ebola

Prior to the Company's still it was thought that infection with Ebola virus (family Marburgviruses) does not give any chance of recovery for all types of primates. In the case of fever probability of fatal human care is 90%.

Hemorrhagic (associated with large blood loss), Ebola (GLE) is considered quite rare, but one of the most dangerous viral diseases known to mankind. In the U.S. and a number of other countries the basis for significant investment in research GLE was September 11, 2001. Then there was concern among scientists that the virus could be used by terrorists as a biological weapon.

It is expected that the vaccine "prime-booster" will make a real revolution in the fight against Ebola virus

GLE for the first time the virus has been found in 1976 in the western equatorial province of Sudan and in the border area with him to Zaire (now the Democratic Republic of Congo). Since then, the disease has died about 1200. Basically, it was the people of Central Africa, where up to still lyakalizuetstsa and hearth disease.

The disease is transmitted through direct contact with blood or tissues of infected humans and some animals. Once in the blood, the proteins of the virus violate its clotting. As a result, starts strong internal hemorrhage, blood also flows through the pores of the skin and eyes.

It is assumed that the U.S. virusolyagami developed a new vaccine that works on enhancing responsible for the overall immunity of T cells, will make a revolution against the GLE. The preparation consists of two components. First — a prime, which contains a small region of DNA on the surface of the viral envelope, and the second — cold booster or attenuated virus.

Head of research group Dr. Nancy Selivan, argues that with the introduction of the vaccine in primates developed an immunity to the pathogen GLE. Moreover, the drug was effective in the treatment of disease. Despite the apparent progress, the scientists say that the final creation of a vaccine that would act against all variants of the virus GLE, more time is required. One of the central questions virusalegii is the following: it is due to the peculiarities of how the T-cell immune response to a possible Marburgviruses? The discovery of this mystery and help to create a single vaccine for all variants of this dangerous disease pathogens, according to a publication of the journal "PLoS Pathogens".

Ebola millions of years, and it is the remains of a human DNA

The authors of another article, also published in «PLoS Pathogens», American biologists from Princeton Pensilvanskaga Research Center and the Institute of Cancer Research at the Fox Chase Center, argue that despite the relatively recent discovery of the virus GLE, people and animals are faced with this disease since prehistoric times. This is indicated by fever virus fragments found in human DNA, and the genetic material of various mammals opossums, rats, bats, and other. Scientists believe that the human race and other vertebrates have experienced several large outbreaks of the disease. Together with its predecessors GLE pathogen DNA in the human genome and found animals and the remains of other viruses. For example, bornavirus that harms the nervous systems of animals and is associated with the development of psychiatric disorders in humans. As the scientists, their footprints left in the DNA, in principle, all of the viral epidemi that humanity had been ill. The fact that the viruses are so-called "Live" objects — they have their own genes, the envelope with special proteins to penetrate into the cell. Since there are no active processes in the virus itself is not leaking, the remnants of the viral genes are usually safe waste in the body. And, as evidenced by the scientists, besides also useful: the viral DNA into fragments is not something accidental, they point to the implications of evolutionary selection.

Thus, in one of these "debris" American geneticists discovered viral gene that encodes a protein complex glycoprotein. According to the researchers, the cells that themselves produce viral glycoprotein, may be more resistant to infection by dangerous viruses.



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