Three Russian developer of vaccines against HIV unite for the final stage of the research, told RIA Novosti Acting CEO FSIS SRC VB "Vector" Eugene Stawski. He said that in Novosibirsk A workshop on developing a vaccine against HIV. Three new vaccines are collaborating organizations and experts — representatives of the WHO, Epidemiology and Control of the State Institute of Standardization and Control of Medical drugs (GISCO).
"Order of the Government of the Russian Federation of December 25, 2007 to conduct research for three years has been allocated 1 billion rubles. With these funds, artists have developed three vaccines: Novosibirsk — "KombiVIChvak" in the SSC "Vector" in Moscow — "VICHREPOL" at the Institute of Immunology and Russia in St. Petersburg — "DNA 4" at the Research Institute of Pure Biochemicals together with St. Petersburg State University, "- he said. According Stavski, all vaccines have successfully been certified in GISCO. For the Novosibirsk and St. Petersburg vaccines documents agreed to conduct Phase I clinical trials for the vaccine and "VICHREPOL" — to carry out the second phase. "Testing at these stages and confirm safety of the presence of the immune response. Ahead of the main and the most expensive part of the operation — to check on the effectiveness of vaccines, proof of immune protection in cohort studies, "- said the source. He said that the meeting came to the conclusion that the implementation of the final stage necessary to bring together all three developers. This proposal is approved the joint coordinator of the WHO-UNAIDS Saladin Osmanov, who confirmed that in Western countries the development and testing of vaccines against HIV / AIDS by large consortia.
"The merger will allow to develop cohort studies, creating control groups in different regions of Russia, as well as to organize complex approaches to HIV prevention and treatment using existing antiretroviral drugs and other techniques," — said Stawski. According to him, the decision of the Government of the Russian Federation on the allocation of the budget for further work on the creation of vaccines is expected by the end of this year. "If the decision is positive, such a consortium will soon appear in Russia," — said the official. As reported at the meeting of the head of the Institute of Immunology Russia Igor Sydorovych, of the many hundreds of candidate vaccines around the world so far managed to fix the performance of only one — RV144, developed in the USA and tested in Thailand. Her tests have cost $ 160 million. According to monitoring, level of immune protection was about 30%, assuming a six-fold vaccination during the year. In a group of eight thousand people taking placebo, 74 people became infected with HIV compared to 51 in the same group vaccinated.
"The meeting agreed that such a result is not enough to create a sensational claims about protection against HIV. However, even with such a low efficiency of its use in high-risk groups could save a million lives a year. On the territory of Russia and spread rapidly progressing other genetic subtypes of HIV than in the U.S. and Europe. This means that protection from HIV in Russia can be achieved only through the efforts of domestic experts, "- said Sydorovych, whose words are quoted by the press service of the" Vector ". It also cites the head of the Laboratory of Virology Research Institute of Highly Pure drugs, Biomedical Center Director Andrei Kozlov. According to him, on the basis of the center for advanced clinical research has formed a group of volunteers — about 500 drug users who are most at risk of HIV infection.
"In the creation of a cohort usually takes five to seven years, so we advance this work was carried out in parallel with the creation of the vaccine to be fully ready for Phase III trials. I’m on a lot of international conferences and I can say that the Russian vaccines used the same methodology as that of the foreign counterparts, and they are what they are not inferior in terms of technology and quality of the product. But to prove their effectiveness may only last phase, so in spite of the significant costs and a lack of success, it is essential that it took place ", — he said.
According to the WHO, now there are more than 33 million people living with HIV, half of whom were aged 15-24 years. Recorded 25 million deaths, and the annual rate of new cases is 2.7 million people, or 7.4 thousand cases every day. According to the deputy director of the Institute of Virology, Academy of Medical Sciences Leonid Uryvaeva quoted by the press service of "Vector", in the last three years in Russia recorded 570,000 people living with HIV. "In some regions, the number had reached 1% of the population. Continues to dramatically increase the number of HIV-infected pregnant women and children. In the Samara region are infected every 50th woman in labor (1.8%), in Irkutsk, Sverdlovsk and Tyumen — up 1.2%, while the national average — 0.46% ", — he said.