Bioprintingom tissues and organs engaged in Moscow

  • Bioprinter placed in a special chamber for creating a sterile environment.
  • Bioprinter placed in a special chamber for creating a sterile environment.

Bioprinter placed in a special chamber to create a sterile environment

In Moscow, opened the first laboratory for the 3d-biopechati organs and tissues.

Biopechat organs and tissues of living — a fast growing trend Regenerative Medicine,
designed to restore and fully recreate entire organs of the human body.

According to the supervisor of the laboratory opened in Moscow «3D Bioprinting Solutions» Professor Vladimir Mironov, new technology in the near future, mankind has completely rid the need for donor organs and solve the problem of biocompatibility of transplanted organs and tissues. After all, biopechat involves the use of autologous stem cells, or more precisely, their conglomerates — spheroids of which is printed on Biogel and future tissue or whole body. 

As explained at the opening ceremony of the lab «3D Bioprinting Solutions» Mironov professor, developed the technology is not limited to the actual 3D-biopechatyu — first built a computer model of the future body with all its anatomical and tissue characteristics, including vascular pattern. The most important stage — the selection of stem cells from their own fat tissue of the recipient, which uses a cell sorter, and then — to provide cellular spheroids, building material for tissue or organ.

  • Engineers are working on a lab on a chip of the nephron.
  • Engineers are working on a lab on a chip of the nephron.

Engineers are working on a lab on a chip of the nephron

The know-how of the laboratory — a special bio-gel, which prevents cellular spheroids stick together ahead of time, the cartridge nozzles bioprintera and through which they "drip" in accordance with established computer model to "biobumagu." Camoproizvolnoe fusion cell conglomerates — the most important property of biota, without which biopechat organs and tissues would be impossible, cell spheroids were deposited on the substrate construction, merge into a single layer, which merged (fused) to the next layer of the spheroids. And so, layer by layer, it turns dimensional object.
Professor Mironov said that the merger is due to surface tension forces, without any of the biological processes.

Printed on bioprintere tkaneinzhenernaya design is then placed in a bioreactor filled with a variety of growth factors and other substances necessary for the accelerated maturation of tissue. Vladimir Mironov stressed that the tissue (organ) through directly to the vascular pattern, for it is loaded into cartridges bioprintera conglomerations of cells forming blood vessels. According to him, to date, been obtained biological objects, including three types of cells.

Laboratory «3D Bioprinting Solutions» will work in collaboration with the Institute of Gene Biology, Russian Academy of Sciences. Laboratory of Molecular Genetics of Cancer, led by Professor Sergei Kiselyov will be a "supplier" of stem cells for cell spheroids. The plans of the joint work of the union — a device used to test the functioning of the cells and the development of a robotic system that provides cellular spheroids with a capacity of 10 million drops per second. According to V. Mironov, the minimum performance required to scale the technology biopechati.
Another immediate challenge — the creation of its own bioprintera surpassing world counterparts. "The design of this bioprintera already developed — said the scientist Vladimir Mironov, head of the Laboratory — now we are looking for who could do it, and then expect to get a patent, and only then send the article in the journal« Science ».

The future plans of the laboratory «3D Bioprinting Solutions» — biopechat kidney in 2030, which is now the engineers and designers are working to create a microfluidic device receiving renal nephron — cells whose main function — filtration and reabsorption. The first stage of this work — the development of artificial nephron on the chip.

Author:Tatiana Zimin.Photo by the author.

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