According to the World Health Organization in the world today there are up to 13 percent of infertile couples, with 50 percent of the reason lies in a man's health, and in 50 per cent — in the women's. Among the female factor infertility tubal factor predominates — obstruction of the fallopian tubes, or lack thereof, after various surgical procedures. In this case, the only possible method of conception is IVF — in vitro fertilization method, or, as they used to say "test-tube baby."
History of IVF
Back in 1958 the Briton Robert Geoffrey Edwards (Robert Geoffrey Edwards) started research on the fertilization of eggs outside the body. He only developed the technology of IVF, for which in 2010 was awarded the Nobel Prize in physiology or medicine. The world's first "test tube baby" also appeared in Britain in 1978. The girl's name was Louise Brown. Doctors USSR not far behind the British. In February 1986, thanks to the work of the group of scientists from the Scientific Center for Obstetrics, Gynecology and Perinatology, under the guidance of the late Professor Leonov was born the first Soviet eco-girl, Lena. In the same year, was born in Leningrad, the first ECO-boy, Cyril. By the way, Lena has itself become a mother.
How is IVF?
The first stage— This hormonal stimulation of the ovaries, which leads to the fact that there is more than one egg. Their number depends on the IVF protocol, the dose of hormones that are assigned to the patient. The average is formed from 5 to 20 eggs — while no drug naturally in women only one egg matures. For IVF is not enough.
Tier ovarian stimulation lasts about 10 days, during which the patient would have to go to the clinic 2-3 times ovarian ultrasound monitoring.
The next important step— This fence eggs and, on the same day — fertilization. Egg collection goes under intravenous anesthesia, it takes about 10-15 minutes, no discomfort, the patient does not feel, the entire procedure takes place without any incisions in the abdomen, transvaginal, ultrasound under control. At the same time, the spouse passes on sperm fertilization.
After that, doctors join the egg and sperm, resulting in the formation of the embryo.
In fact, this is not a test tube, as is usually said, and in Petri dishes on special nutrient media complex embryological stage takes from three to five days. If the husband's sperm is more or less normal, then fertilization occurs by simply adding sperm to the eggs. If sperm maloaktivna, use the method of ICSI — intracytoplasmic sperm injection, where the sperm injected into the egg by hand.
The third stage— This transfer of embryos into the uterus. It is absolutely painless step, it takes only a few minutes, no discomfort while the patient is not experiencing an hour and she can leave the hospital.
Two weeks after the embryo transfer can see the result of Reproduction. To date, the probability of getting pregnant on the first try on the average is 45 percent. Of course, this probability depends on many factors, and, for example, for male factor infertility, low sperm quality, the probability of getting pregnant is less than about 35 percent on one attempt.
Teramoto protocol or Japanese protocol
Currently, there are a few minutes of the first phase of IVF — ovarian stimulation.
Standard or long protocolcharacterized by active stimulation of hormone ovarian stimulation for a longer time than other protocols. The result is up to 20 eggs.
Short protocolstimulation, in which the stimulation is shorter, resulting in fewer eggs of poorer quality.
Teramoto protocol (Japanese protocol). Recently, the global trend is leaning to the protocols with minimal stimulation and minimal hormonal stress, during which the task is not to get as many eggs as possible and quality eggs.
The only IVF clinic in Moscow, which actively uses the protocol Teramoto — a "Deltaklinik." Thus it at any chosen protocol, an individual approach to each patient in the selection of the dose of the drug. This is due to the fact that the qualifications of clinical specialists allows to predict the risk of developing ovarian hyperstimulation syndrome and other complications.
Advantages of the protocol Teramoto
When Teramoto protocol can avoid serious complications such as:
1. ovarian hyperstimulation syndrome (occurs in 3-5 percent of cases), ovarian apoplexy, ovarian torsion.
2. Furthermore, since the OPU is a smaller diameter needle, this procedure is less damage from ovarian tissue.
3. Oocytes, which are obtained using the protocol Teramoto, better;
4. The absence of any pain in a patient using this stimulation protocol;
5. An important feature of the protocol Teramoto — is careful and gentle effect of drugs on the body of a woman. In the end, even the "manipulation" of the Japanese component of IVF protocol manages a third cheaper.
As a result of IVF protocol Teramoto is less stress for the female body. Not surprisingly, in Japan, this type of protocol is most commonly used at present, and is used successfully for over 20 years. Experience of using it in the "Deltaklinik" also suggests that the Japanese protocol in Moscow — a great future.