Grapefruit juice does not fit well with medications. Back in 2000, scientists have shown that use it in conjunction with heart medications can not. The fact that the structure of grapefruit juice is a substance capable of reacting with some drugs by increasing their velocity in the suction
This feature citrus drink is especially dangerous for the elderly, who often take pills "from the heart" and often with calcium-fortified drink grapefruit juice. Excessive action of the heart of funds can cause life-threatening complications. In general, the interaction of grapefruit juice with drugs intended for oral administration, is unpredictable.
For the list
At the initiative of scientists, some American magazines published a comprehensive list of drugs that are combined with grapefruit juice may behave unpredictably. For example, women who take birth control pills and drinking Grapefruit juice one day may find that they are a little bit pregnant, and those who are taking antidepressants — that they were not a little depressed. The range of "miracles" is dependent on the drug.
But the biggest danger is the combination of malicious juice and lipid-lowering drugs. While the liver is "occupied" by dismantling parts of grapefruit ingredients, drugs circulate throughout the body, and their concentration in the blood increases, reaching the dangerous levels when there are any side effects immediately. The main problem — as in the above case — is muscle damage and acute renal failure.
So, forget about the grapefruit juice (fresh squeezed especially) will have to, if you are taking one of these drugs (it should be noted that many of them are very popular in Russia)
- Anxiolytics: alprazolam, buspirone, midazolam, triazolam
- Antiarrhythmic: amiodarone, quinidine
- Antibiotics: clarithromycin, erythromycin, troleandomycin
- Antihistamines: fexofenadine
- Anticoagulants: Warfarin
- Antiepileptic: carbamazepine
: Carvedilol Beta-Blockers
- Calcium channel blockers: diltiazem, felodipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil
- Hormonal preparations, containing: cortisol, estradiol, methylprednisolone, progesterone, testosterone
- Immunosuppressants: cyclosporine, sirolimus, tacrolimus
(Lipid) atorvastatin, fluvastatin, lovastatin, simvastatin HMG-CoA reductase
- Serotonin reuptake inhibitors (antidepressant) sertraline, fluvoxamine
- Xanthines: theophylline
- Treatment of benign prostatic hyperplasia: Finasteride
- Opioid analgesics: alfentanil, fentanyl, sufentanil
- Antivirals: amprenavir, indinavir, nelfinavir, ritonavir, saquinavir
- Worming: albendazole
- Antifungal: itraconazole
- Cough: dextromethorphan
- Anticancer: cyclophosphamide, etoposide, ifosamid, tamoxifen, vinblastine, vincristine
- Repotentery: sildenafil, tadalafil
It should be emphasized that the lists active substance, and trade names of drugs can be very diverse. The name of the active substance is written on the packaging and in the instructions given to the drug.
Tea, coffee, borzhom
After reading this list, which was about five dozen active ingredients (which is several hundred trade names), a logical question arises: what, then, can and should be wash down medication if all that serious? How to be in respect of mineral water, other juices, tea, coffee, milk?
There are several drugs that should not drink water, but quite some liquid — to achieve the desired effect.
For example, erythromycin is better to wash down any alkaline mineral water (Essentuki number 4, № 17) or milk. Alkaline mineral water required in the case of aspirin. It is also recommended to wash down with a sulfonamide (biseptol, sulfalen, sulfodimetoksin). Mineral water also increases the absorption of dipyrone, tetracycline sedatives.
Indomethacin or reserpine, because of the chemical characteristics of the active ingredient, it is recommended to wash down with milk. The same applies to a fat-soluble vitamins (A, E, K, A), and iodine.
But the same milk reduces the effectiveness of drugs that are similar in structure to the protein — cardiac glycosides, caffeine, anti-ulcer agents (cimetidine, ranitidine). Do not follow them wash down enzymes (pancreatin, mezim). Milk inactivates tetracycline drugs as contained in milk calcium reacts with components insoluble drug compound. Sometimes in the prescribing information can be found direct reference to the inadmissibility of the use of milk. For example, the manufacturer hilak Fort points out, "to take a small amount of liquid (except milk)."
Fruit juices, especially acidic, nullify the effect of taking, for example, antacid drugs that reduce gastric acidity. Do not drink juice or compote cardiac glycoside (digoxin, etc.) and sulfonamides (streptocide sulfalen etc.), which are alkalis their chemical nature (and fruit juices contains acid). It is known that sour fruit juices and vegetable adversely affect the effectiveness of such antibiotics, such as erythromycin, sumamed, ampicillin, and conversely, significantly potentiate the activity (up to toxicity) aspirin, nitrofurans (furagin, furazolidone), paracetamol, ibuprofen.
Refrain from zapivaniya tablets tea. Tannin contained in it, can form insoluble compounds and simply make precipitate some drugs (papaverine, codeine, aminophylline, cardiac glycosides, etc.)
Coffee is also not well suited, for example, when taking sedatives. This also applies to many other drugs.
Sometimes, in order to reduce the influence of drugs irritating advisable to wash down his jelly. It is necessary to remember that slimy broth slows down the absorption of the drug.
Antibiotics can not drink "Coke" or "Baikalom", otherwise the lumen of the gastrointestinal tract can form insoluble complexes of iron, which reduces the effectiveness of antibiotic therapy.
The only remedy for universal zapivaniya tablets was and remains water (but not to ice and room temperature). Usually enough quarter cup, but in special cases (salicylates) may be required, and more.
Vodka, herring, tablet
There is one more important, particularly for Russia, the question — how do alcohol? Vodka, brandy, wine, beer — how they are combined with a variety of drugs? The short answer — alcohol and drugs do not mix. That is, if you assigned
Some medicines are combined with alcohol are converted into a volatile mix that could permanently disable or even kill a person. Remember the domestic film "Criminal talent." The heroine Alexandra Zakharova fluster men in a restaurant liquor, which was dissolved clonidine, and then fleece them. The method was at one time very common among prostitutes who wanted to get money from a client without providing the agreed services.
Metronidazole in combination with alcohol can also cause long become sad, as it causes an effect similar to the action of the anti-alcohol drugs (teturam, Antabuse, esperal), even coma.
Also very unfriendly with alcohol include antibiotics, antidepressants, drugs and many other pharmacological groups. Then choose one: either drinking or treated.
Read Finally, the instruction
How can remember — that the wash down? In fact, not be a huge table for itself that fit attach to a wall — so many dif
ferent combinations possible, even when receiving a drug. And if you have to take several medicines — there can be up to near panic.
In fact, everything is much easier. First of all — pomuchali questions your doctor about the drug regimen. Second — remove it from the trash can just throw out an instruction from the purchased medications and study it carefully.
If the instructions are not specifically mentioned, what is to be wash down this or that drug — wash down with boiled water at room temperature (about 20aboutC). Abstain from alcohol and, just in case, remove ummm grapefruit juice. Who knows what.