Systemic lupus erythematosus

Systemic lupus erythematosus.

Systemic lupus lupus (SLE) — a serious disease in which the immune system perceives its own cells as foreign and begins to deal with them. In this case, the substance produced by the body, damaging many organs and tissues, vessels, skin, joints and organs (kidneys, lungs, heart, liver, brain, etc.). Among patients with SLE nine out of ten — women, and half of them are the first symptoms appear between 15 and 25 years old.


The cause of the disease is still unknown. However, the scientists suggest that a role in its occurrence can play against a viral infection of the genetic defect immunity. Very often disease develops after excessive sun exposure, childbirth, abortion, severe emotional distress. In many cases of systemic lupus erythematosus in the past was allergic to medicines and foods. Likely to contract sharply increased if the tribe have relatives suffering from SLE.

What's going on?

Most disease begins gradually. Patients concerned about weakness, weight loss, fever without apparent cause, pain in the joints. Less commonly, there is an acute onset of disease (fever, an acute inflammation of the skin, joints). In dalneyyshem SLE flows in waves, with each exacerbation in the process may involve the new organs and tissues.

The symptoms include systemic lupus erythematosus skin lesions in the form:

  • redness of cheeks and nose — the so-called "butterfly"
  • redness of the neckline, the growing excitement, exposure to the sun, frost and wind;
  • rash as red rings with a pale skin inside the ring

Often affects the mucous membranes of the mouth and lips — the so-called aphthous stomatitislupus cheilitis.A common complaint is pain in the joints symmetrically located both in large (knee, shoulder) and in small (joints of the hand). Concerned about pain in the muscles.

There is inflammation of the serous membranes (the pericardium, pleura, peritoneum). In addition may be affected kidney (in nearly all cases), liver, lungs, heart, brain.

As part of SLE often develop antiphospholipid syndrome (APS) — the body appears substances (antibodies) that damage the phospholipids. Since phospholipids are involved in the construction of the cells from which the human body is built, thendisease becomes particularly severe.

Diagnosis and treatment

The diagnosis of "systemic lupus erythematosus" sets rheumatologist on the basis of the patient's complaints: gratuitous weight loss and fever, redness of the face in the form of a "butterfly", joint damage, kidney, heart, etc. In SLE necessarily prescribe blood count (identify common symptoms of inflammation), blood test for lupus, the study of immunity, clinical analysis of urine, x-ray examination of the lungs, echocardiography (ultrasound of the heart). The physician must not only identify the disease, but also to understand what damage she could cause a patient.

Patients with systemic lupus erythematosus require continuous observation and years of combined treatment by a physician or rheumatologist. The sooner it is started, the better.

Treatment of SLE begin with hormonal anti-inflammatory drugs (corticosteroids). To mute the raging immune responses are used immunosuppressants. Glyukortikoidy often prescribed together, and immunosuppressive drugs. Naturally, this raises the risk of serious adverse reactions, so need constant medical supervision.

In the case of aggressive disease course in patients prescribed plasmapheresis. Patients with SLE are prohibited sunbathe and supercool, have avoided the operations and administration of vaccines, therapeutic sera.

Like this post? Please share to your friends: