A kidney from stem cells for the mouse!

The fact that the stem cells — a unique building material for our body, is known to many, but more recently, scientists have started to use it, starting to grow organs. This year, the experiment has been put on the mouse, which farmed successfully transplanted a kidney! The mouse is alive and well, and the new body is functioning perfectly.

Hristodolus Ksinaris (Christodoulos Xinaris) of the Mario Negri Institute for Pharmacology and his colleagues raised the kidneys from stem cells of mouse embryos. This laborious process took a long time. As reported in an article in the edition of the Journal of the American Society of Nephrology, the researchers first obtained from stem cell organelle composed of nephrons — the basic elements of the kidneys.

Thereafter, the resultant was heated in a chemical organelles broth containing vascular endothelial growth factor (VEGF), which resulted in growth of blood vessels. Then these structures were transplanted in the kidney of live mice and injected them additional VEGF. This caused more extensive growth of blood vessels and the formation of tangles, where the blood comes into contact with the cleaning nephrons.

To verify the effectiveness of the transplanted kidney, the researchers injected the animals albumin proteins marked with a special marker. It was found that cultured kidney successfully filtered proteins from the blood, and hence perform the function of the organ.

"We first received a functioning renal tissue from individual cells — said Ksinaris. — Grown authority may be isolated from the blood of large molecules. It gives us resolve. We will create a similar fabric for man. "

Now researchers are connecting channels of the kidneys to the bladder. They also try to grow in mice from human liver cells.

It is worth noting that such attempts have already been made by scientists from Japan. Moreover, in these studies were also involved mice.

Less important part of the new research is the way to obtain stem cells. In recent years, more authoritative organizations are inclined to think that the removal of these materials from human embryos is unethical. In this regard, of particular interest scientists associated with alternative sources such as amniotic fluid and bone marrow.



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