Prenatal screening for trisomy I trimester of pregnancy

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Prenatal screening for trisomy I trimester of pregnancy (I trimester biochemical screening for pregnancy, "double test» I trimester)complex research being undertaken to pregnant women to assess the risk of fetal abnormalities: Down syndrome (trisomy of chromosome 21), Edwards syndrome (trisomy 18), neural tube defects (NTDs).

What indicators are included in the "double test» I trimester?

  1. Human chorionic gonadotropin free (free hCG, free beta-hCG); 
  2. Protein associated with pregnancy (PAP-A).

What are the indications for a "double test"?

Prenatal screening for trisomy I trimester of pregnancy is carried to all pregnant women. Specific indications include:

  • women over the age of 35 years;
  • the presence of a child (or a history — of the fetus aborted pregnancy) with genetically confirmed Down syndrome and other chromosomal diseases, congenital malformations;
  • hereditary disease in the immediate family;
  • radiation exposure or other harmful effects on one's spouse before conception.

At what stage of pregnancy is carried out I trimester prenatal screening?

Optimal timing of the survey — from 11 to 13 weeks of pregnancy.

What preparation is needed for a "double test» I trimester?

For this study, you must have the results of fetal ultrasound made no earlier than one week prior to analysis.

What are the dates of performance analysis?

1 day.

How are the results of a "double test» I trimester?

The results of calculating the risk of chromosomal abnormalities are not the basis for a diagnosis, and are an indication for further special methods of investigation on the advice of the obstetrician-gynecologist.

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