Laboratory studies have shown that the oligosaccharides contained in apples, kill up to 46 percent of human colon cancer cells, and by a wide margin superior to all of the most commonly used drugs for chemotherapy at any stage.
Unlike the toxic chemotherapy drugs, oligosaccharides are natural, health enhancing compounds contained in a large number of vegetables and fruits.
Currently, colon cancer is the second leading cause of cancer death among women worldwide and the third reason — that of men.
Standard chemotherapy drugs used in the treatment of colon cancer can achieve only partial success, and have serious side effects such as coronary spasm, neurotoxicity, anemia and immunosuppression.
The researchers focused on apples as a natural remedy for the treatment and prevention of colon cancer, as these fruits are the most widely consumed fruit in many countries, and has already demonstrated its advantages in the treatment of cancers of the breast, ovary, lung, liver and colon.
Apple oligosaccharides were considered in this study because of their anti-cancer properties have been confirmed in previous studies, and getting them out of the apple pomace — waste remaining in the development of apple juice on an industrial scale — can be much cheaper.
Chinese researchers from the University of Xi'an received polysaccharides (pectin and other fibers) of apple pomace and natural pectinase treated them to share their molecules into smaller oligosaccharides (which accounted for one molecule would only 9:57 of units of sugar).
Then, the resulting oligosaccharides were added at various concentrations in human cultured cells HT29 colon cancer, researchers then compared these results with exposure to the most commonly used chemotherapy drugs for cancer of the colon.
For each concentration tested, oligosaccharides surpassed drugs for chemotherapy by induction of programmed cell death (apoptosis).
For example, at a concentration of 0.9 micrograms per ml (about 0,9 PPM), oligosaccharides 17.6 percent kill colon cancer cells after 36 hours, while the chemotherapy drug killed only 10.9 percent (higher concentration of 1.3 micrograms per ml).
But more important is that the apple oligosaccharides are not toxic to normal cells, and hence they can be used in higher concentrations than preparations chemistry.
At a concentration of 9,0 PPM, oligosaccharides kill 46 percent of colon cancer cells (chemotherapy drugs simply not tested at this level).
Recently, oligosaccharides is receiving increasing attention as a product strengthens our health and is likely to enriching a number of foods that you already eat (ie FOS).
They were found during research for improving the health of intestinal flora, research on blood sugar control and modulate the immune system.
In nature, oligosaccharides found in many plants (fruits, vegetables, and even algae), as well as honey and milk.
They can also be formed due to a destruction of more complex carbohydrates fruit (e.g., pectin) pectolitic enzymes as is done scientists in this study.
To some extent, this reaction can occur by eating fruits themselves, because apples contain about 1.5 per cent of pectin and pectinase enzyme itself.
Nevertheless, it should be noted that almost all produced apple juices contain virtually no active enzymes or pectin, and contain only about 10 percent healing compared to the polyphenol raw fresh apples.
It turns out that, as usual, eating unprocessed and fresh fruit was much healthier than the consumption of the processed version.
This new study provides further evidence of how apples are good for health, and how powerful anti-cancer effect is contained in these oligosaccharides, even at low concentrations.
The fact that these oligosaccharides can be produced from cheap and available from the industrial production of apple juice (annually produces about four million tons of oil cake), opens in the future opportunities for low-cost natural medicine.