- RCTU Mendeleyev
Scientists from the Institute of Emergency Sklifosovsky and RCTU Mendeleev developed a new material for medicine. Activated carbon with a surface modified polypyrrole, can be widely used in hemosorption — method of treatment aimed at cleansing the blood. Efficacy and safety of the new material in the tested series of experiments. The results of the work were published in the March issue of the journal Carbon.
Carbon materials, modified conductive polymers are widely used in various fields. For example, such active materials are being developed for supercapacitors and fuel cells. Also, they find their application in medicine. In numerous articles refers to the creation of artificial muscles, biosensors and targeted drug delivery systems.
The authors of the above article are looking for a way to create carbon materials for hemosorption — blood purification adsorbent. This treatment is often necessary after acute poisoning medication or chemical poisons. Seemingly ordinary activated carbon — a perfect solution for this case. The huge surface area allows it to serve as a very effective adsorbent of toxic organic substances, and the positive charge on some atoms — to bind negatively charged ions of harmful substances. However, folk legends about the complete harmlessness of activated carbon in any dose for this case are greatly exaggerated. Since about 30 years ago it was shown that activated carbon adversely affect erythrocytes, often destroying them in contact.
So many years, scientists are looking for a way to modify the activated carbon to improve its biocompatibility. Russian research team for the first time proposed a new approach for this area: spending on the surface of commercially available carbon AG-3 electropolymerization of pyrrole to form a conductive polymer. To test the effectiveness of this method, the researchers conducted several series of different experiments.
The first of these characteristics were investigated electrochemical conductive carbon materials. Thus, one of the most important indicators of biocompatibility is the open circuit voltage that persists in the material after opening the circuit to which he belonged. In this figure biocompatible materials should be in the range from — 0.15 to 0.05, while it is activated carbon hundred mV. As shown by experiments conducted in saline polypyrrole after the modification value of this index falls and reaches the maximum allowable limit.
After studies were carried out by specialists of hemoglobin in a mixture of activated carbon with red blood cells. Contact net AG-3 leads to the death of red blood cells, and appear in a solution free of the hemoglobin molecule. A similar solution is a modified carbon molecular hemoglobin was observed. Finally, studies were carried out of the adsorption activity of the new material, wherein a model used hlorpotiksen toxic substances. The experimental results were surprising: activity of the modified polypyrrole was increased by 25 percent. The nature of this phenomenon is still necessary to investigate, but it once again confirms that the carbon material obtained by researchers with the modified surface opens up new possibilities in medicine detoxification.
Source of information:
Mogely Sh. Khubutiya, Mark M. Goldin, Andrey A. Stepanov, Vladimir A. Kolesnikov, Sergey S. Kruglikov, The effect of electrochemically polymerized pyrrole on the physicochemical properties and biological activity of carbon materials, Carbon Volume 50, Issue 3, March 2012