Russian scientists have developed a means to protect the kidneys from infection


Scientists have already submitted an application to the Fund "Skolkovo" for a grant to conduct clinical trials of new agents. In the best scenario, in three to five years, this drug may occur in pharmacies, said the project manager.

The substance is an antioxidant of class "Skulachev ions" can effectively protect the kidneys from the effects of severe bacterial infection — infection pyelonephritis, Russian scientists have proved in the course of experiments, the results of which are published in the journal Proceedings of the National Academy of Sciences.

 Mitochondrial antioxidants ("ions Skulacheva» (SkQ)) created in the Institute of Physico-Chemical Biology, Moscow State University named after Belozerskii under the leadership of Vladimir Skulacheva. They can accumulate in mitochondria — "energy plants" of the cells which are most affected by active oxygen species (free radicals).

Now, a group led by Dmitry Zorov Belozersky Institute of experiments on rats showed that one type of "ion Skulacheva» — SkQR1 — can facilitate the flow of infectious pyelonephritis. It works like this: the bacteria causing pyelonephritis, activated white blood cells — white blood cells. This is a normal immune response, but it can "perehlestnut" and lead to kidney damage. Occurs in leukocytes increased production of reactive oxygen species, and these forms themselves begin to kill cells of renal epithelium, — Zorov said.

Substance SkQR1 reduced oxidative stress and prevented the development of inflammation.
"We indirectly influence the immune response, preventing it perehlestnutsya. Roughly speaking, this is an anti-inflammatory ", — Zorov said.

He noted that before he and his colleagues have shown the effectiveness of SkQR1 in renal ischemia, as well as "compression syndrome" or "crush syndrome" — severe kidney disease that develops during prolonged crushing of limbs (for example, people under the rubble). In addition, the scientist said, SkQR1 is highly effective in stroke — it reduces the area of brain damage and improves functional recovery.

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