Transplantation of artificial trachea and larynx using patient’s own cells

The world’s first transplant of an artificial trachea and larynx using the patient’s own cells held in Russia


Photos: Valentine Mishchenko / Yugopolis


The world’s first transplant of an artificial trachea and larynx using the patient’s own cells held on June 19 in Russia in Krasnodar Regional Clinical Hospital № 1. prof.S.V.Ochapovskogo. This operation is part of a project carried out under a grant from the Government of the Russian Federation to attract leading scientists to Russian universities.

Transplantation had a professor of regenerative surgery at the Karolinska Institute Paolo Macchiarini (Paolo Macchiarini) (Stockholm, Sweden) and Head of the Department of Oncology and Thoracic Surgery of the Kuban Medical University, corresponding member of the Academy of Medical Sciences Vladimir Porkhanov. The patient was transplanted trachea, built on the frame of the nanocomposite material seeded own cells isolated from bone marrow. Professor Paolo Macchiarini led an international team of scientists, which also included experts Nanofiber Solutions (OH, USA), manufacturers of the framework and Harvard Bioscience (Boston, USA), the developers of "personal" bioreactor, created specifically for the patient. Preparation for this most complex transplant took more than six months.

Created bioprosthesis — an exact copy of the larynx and trachea patient — allows you to replace the diseased organ and avoid rejection. Looks like a tube of a flexible plastic, while the porous material on which the patient’s own cells are seeded, isolated from bone marrow. Then, the structure is placed in the bioreactor, where the attachment of cells to the framework. Within 48 hours, forming the basis of the trachea. In the future, the patient not only her tears away, but rather transplanted organ itself begins to "adapt" to new conditions. All work on seeding was carried out in the frame CMC lab number 1. It was attended by specialists of the clinic, which took place in an internship at the Karolinska Institute.

Candidates for transplantation were selected in February this year after a discussion on the international video a consultation, which was attended by thoracic surgeons KKB number 1 (Krasnodar), the Russian State Scientific Center of Surgery. Acad. BV Petrovsky Academy of Medical Sciences (Moscow), the Karolinska Institute (Sweden), Karredzhi Clinic of the University of Florence (Italy) and the University Hospital of Texas (USA). They have extensive damage to the trachea, formed in the aftermath of trauma.

The first patient — 33-year-old Julia T. from St. Petersburg — is no exception. Eighteen months ago, she became the victim of a car accident with severe consequences. She formed a scar stenosis of the trachea, because of which there were serious difficulties with breathing and speech. She underwent several surgeries at the trachea, which did not give significant results, in fact — have worsened. This transplant was the only chance for Julia for recovery and a full life.

The operation, which lasted five and a half hours, was successful, and in the operating Julia was able to say a few words. She asked Professor Macchiarini in Spanish, which is a little know and thanked for the fact that "Now, at last, be able to play and talk with his young son".

In Krasnodar, watch the transplantation technique, which was broadcast on the big screen, participate in discussions, experts have come from the U.S., Norway and Germany. One of them, Mark Holtermanu (Mark Holterman), professor of surgery in pediatrics at the Center of Peoria (Illinois, United States) this summer to be with Professor Macchiarini do transplant two year old boy from South Korea who was born without a trachea. Dr. Holterman highly appreciated the work of his colleagues and the Krasnodar surgeons. He stated that he had witnessed a unique event.

"This operation requires a very sophisticated and accurate preparation as well — jewelry techniques, which has been demonstrated in Krasnodar", — he added.

David Green (David Green), president of Harvard Biosciences, said that the event — an important step in the development of regenerative medicine.

"We are happy to see the result — the patient could help with regenerative technologies. We congratulate Professor Macchiarini with another achievement in this area and excited about the new collaboration with Professor Porkhanova and Krasnodar Regional Hospital, where over the past two years, held about 80 transplant donor heart, "- he said.

Sam Paolo Macchiarini said:

"The fact that the world’s first transplant of an artificial trachea and larynx with technologies of regenerative medicine is held in Krasnodar regional hospital, not an accident. This clinic — one of the best I’ve seen in Europe. It has accumulated vast experience in transplantation of organs and work very skilled thoracic surgeons. "

Author methods of creating and trachea transplant using technologies of regenerative medicine Paolo Macchiarini to date has spent more than ten such operations. First — using donor obesklechennogo frame (one of which was held in December 2010 at the Russian Research Center of Surgery named after Petrovsky RAMS) and three (including transplantation in Krasnodar) — on the basis of an artificial framework.

In 2011, Professor Paolo Macchiarini, together with the Kuban State Medical University and CMC № 1. Professor S. Ochapovsky Megagrant won the Russian Government on the implementation of the research, clinical and educational project in the regeneration of the respiratory tract and lung, the result of which should be to build the country’s first International Centre for Regenerative Medicine.

More information about the project can be found at www.regmedgrant.com


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Transplantation of artificial trachea and larynx using patient’s own cells

The world’s first transplant of an artificial trachea and larynx using the patient’s own cells held in Russia


Photos: Valentine Mishchenko / Yugopolis


The world’s first transplant of an artificial trachea and larynx using the patient’s own cells held on June 19 in Russia in Krasnodar Regional Clinical Hospital № 1. prof.S.V.Ochapovskogo. This operation is part of a project carried out under a grant from the Government of the Russian Federation to attract leading scientists to Russian universities.

Transplantation had a professor of regenerative surgery at the Karolinska Institute Paolo Macchiarini (Paolo Macchiarini) (Stockholm, Sweden) and Head of the Department of Oncology and Thoracic Surgery of the Kuban Medical University, corresponding member of the Academy of Medical Sciences Vladimir Porkhanov. The patient was transplanted trachea, built on the frame of the nanocomposite material seeded own cells isolated from bone marrow. Professor Paolo Macchiarini led an international team of scientists, which also included experts Nanofiber Solutions (OH, USA), manufacturers of the framework and Harvard Bioscience (Boston, USA), the developers of "personal" bioreactor, created specifically for the patient. Preparation for this most complex transplant took more than six months.

Created bioprosthesis — an exact copy of the larynx and trachea patient — allows you to replace the diseased organ and avoid rejection. Looks like a tube of a flexible plastic, while the porous material on which the patient’s own cells are seeded, isolated from bone marrow. Then, the structure is placed in the bioreactor, where the attachment of cells to the framework. Within 48 hours, forming the basis of the trachea. In the future, the patient not only her tears away, but rather transplanted organ itself begins to "adapt" to new conditions. All work on seeding was carried out in the frame CMC lab number 1. It was attended by specialists of the clinic, which took place in an internship at the Karolinska Institute.

Candidates for transplantation were selected in February this year after a discussion on the international video a consultation, which was attended by thoracic surgeons KKB number 1 (Krasnodar), the Russian State Scientific Center of Surgery. Acad. BV Petrovsky Academy of Medical Sciences (Moscow), the Karolinska Institute (Sweden), Karredzhi Clinic of the University of Florence (Italy) and the University Hospital of Texas (USA). They have extensive damage to the trachea, formed in the aftermath of trauma.

The first patient — 33-year-old Julia T. from St. Petersburg — is no exception. Eighteen months ago, she became the victim of a car accident with severe consequences. She formed a scar stenosis of the trachea, because of which there were serious difficulties with breathing and speech. She underwent several surgeries at the trachea, which did not give significant results, in fact — have worsened. This transplant was the only chance for Julia for recovery and a full life.

The operation, which lasted five and a half hours, was successful, and in the operating Julia was able to say a few words. She asked Professor Macchiarini in Spanish, which is a little know and thanked for the fact that "Now, at last, be able to play and talk with his young son".

In Krasnodar, watch the transplantation technique, which was broadcast on the big screen, participate in discussions, experts have come from the U.S., Norway and Germany. One of them, Mark Holtermanu (Mark Holterman), professor of surgery in pediatrics at the Center of Peoria (Illinois, United States) this summer to be with Professor Macchiarini do transplant two year old boy from South Korea who was born without a trachea. Dr. Holterman highly appreciated the work of his colleagues and the Krasnodar surgeons. He stated that he had witnessed a unique event.

"This operation requires a very sophisticated and accurate preparation as well — jewelry techniques, which has been demonstrated in Krasnodar", — he added.

David Green (David Green), president of Harvard Biosciences, said that the event — an important step in the development of regenerative medicine.

"We are happy to see the result — the patient could help with regenerative technologies. We congratulate Professor Macchiarini with another achievement in this area and excited about the new collaboration with Professor Porkhanova and Krasnodar Regional Hospital, where over the past two years, held about 80 transplant donor heart, "- he said.

Sam Paolo Macchiarini said:

"The fact that the world’s first transplant of an artificial trachea and larynx with technologies of regenerative medicine is held in Krasnodar regional hospital, not an accident. This clinic — one of the best I’ve seen in Europe. It has accumulated vast experience in transplantation of organs and work very skilled thoracic surgeons. "

Author methods of creating and trachea transplant using technologies of regenerative medicine Paolo Macchiarini to date has spent more than ten such operations. First — using donor obesklechennogo frame (one of which was held in December 2010 at the Russian Research Center of Surgery named after Petrovsky RAMS) and three (including transplantation in Krasnodar) — on the basis of an artificial framework.

In 2011, Professor Paolo Macchiarini, together with the Kuban State Medical University and CMC № 1. Professor S. Ochapovsky Megagrant won the Russian Government on the implementation of the research, clinical and educational project in the regeneration of the respiratory tract and lung, the result of which should be to build the country’s first International Centre for Regenerative Medicine.

More information about the project can be found at www.regmedgrant.com


Like this post? Please share to your friends: