In 2004 in France, Germany, Italy, Spain, the UK 1.3 million patients were hospitalized for SSTIs, including those due to cellulitis (52.7 percent), local surgical site infection (15.8 percent), diabetic foot (15.3 percent), ulcers (12 percent).
According to expert estimates, the Russian infections of skin and soft tissue ranged from 480 to 700,000 patients a year. Every year in Russia for help in medical facilities are turning to 1.5 million patients with trophic ulcers, about 500,000 patients with diabetic foot syndrome.
Infections of skin and soft tissue are usually caused by multiple microbes at the same time, but the most common cause in most cases is Staphylococcus aureus (S. Aureus). Of particular concern are widespread strains resistant to most antimicrobial agents — beta-lactam antibiotics, aminoglycosides, lincosamides, fluoroquinolones.
Furthermore, hospitals widespread negative bacteria family Enterobacteriaceae (Klebsiellaspp., Enterobacterspp., E. Coli), which are usually resistant to cephalosporins.
When selecting antibacterial therapy approach is essential to the selection of drugs, which is determined by the level of destruction soft tissue, features of the disease and the presence of drug resistance.
Keep in mind that any injury, regardless of its location and origin, always contains a certain amount of micro-organisms (initial microbial contamination). The main purpose of any primary dressing is to stop the bleeding and the prevention of wound infection, regardless of whether it is applied at home, emergency room physicians, doctors clinics or hospitals. In the subsequent treatment is carried out in accordance with the phase of wound healing, the species composition of microbes caught in the wound.
In the last two decades in the treatment of inflammatory processes and septic wounds are widely used new antiseptics (yodopiron, miramistin, dioxidine, lavasept). Ineffective ointment on the basis of vaseline, lanolin (Vishnevsky ointment, ointment ihtiolovaja, streptocidal, eritromitsinovaya, tetracycline, furatsillinovaya, etc.) is almost completely driven out of the practice of treating patients with infection of the skin andsoft tissue. In place of these drugs came ointment polyethylene glycol (PEG) basis.
Particular difficulties always arise in the treatment of patients with infection of the skin andsoft tissue (Trophic ulcers, decubitus ulcers, thermal damage to the skin, post-surgical and post-traumatic wounds) due to allergies, medical and microbial dermatitis, recurrent infection of wounds GOSPITAL highly resistant microorganisms (S.auereus, S.pyogenes, Enterococcus spp., P.aeruginosa, Enterobacteriaceae, Bacteroides sp.). This infection can get into the skin of a patient with a tissue when there is insufficient personal hygiene and hygienic bedding hands of medical personnel, etc. Re-infection is a gross violation of the wound healing process.
In today's world, where common strains of microorganisms resistant to most drugs, the drugs of choice in such situations can be considered silver-containing drugs, such as 2% cream sulfathiazole silver (Argosulfan cream). Cream Argosulfan has high antimicrobial activity against all potential infectious agents soft tissue (Including with venous ulcers and pressure ulcers). The hydrophilic base Argosulfan protects young epithelial cloth, enhanced the growth of the surface epithelium, thereby cream allows you to quickly restore the integrity of the skin. Cream foundation also provides an analgesic effect and tolerability. Slightly soluble silver salt of sulfathiazole allows you to maintain a constant concentration of the drug in tissues and causes no toxicity. Of particular importance is the fact that the long-term observations show a lack of microbial resistance to this drug.
Thus Argosulfan can now be regarded as preparation selecting for topical treatment and prevention of infection of skin andsoft tissue: Venous ulcers, pressure sores, burns, post-traumatic and post-operative long-term non-healing wounds.