Age-related androgenic deficit— Is the lack of androgens (male sex hormone) in the male body that is associated with its natural aging. It is usually develops after age 50, but the first manifestations may occur much earlier — in
Before talking about the causes of age-related androgen deficiency, it is necessary to say about where and how the formation of testosterone.
Testosterone — is main male hormone, the body responsible for:
- growth and development of the genital organs;
- the appearance of secondary sexual characteristics (hair growth on the face, trunk);
- development muscle;
- the formation of male behavior (proactivity, aggressiveness, etc.);
- ability to produce sperm (spermatogenesis);
- features of the distribution of adipose tissue;
- development and structure of the skeleton.
Testosterone produced by Leydig cells in the testes under the influence of hormones produced in the central nervous system, pituitary gland and hypothalamus. These processes are dependent of each other and able to have complex mechanisms of regulation.
Among other things, he testosterone in the blood can be in several variants, or so-called fractions. Active fractions were isolated and inactive Testosterone. For the main effects of testosterone (see above) corresponds to the active testosterone.
There are many theories of aging, leading to the development of age-related androgen deficiency. The main reasons leading to the failure of testosterone are:
- age-related changes in the testes (testicles), accompanied by a decrease in Leydig cells. They are associated with the development of atherosclerosis, reducing blood flow and nutrition of these cells, as well as to "program" the death of these cells (apoptosis);
- age-related changes in the pituitary and hypothalamus, resulting in disturbed regulation of testosterone;
- some genetic predisposition associated with the response of cells to testosterone and some pituitary and hypothalamus.
The main complaint, causing the man to turn to
There have been changes in the skin and
For the diagnosis of age-related androgen deficiency must be glad to laboratory tests:
- study of different factions of testosterone (total testosterone, biologically active testosterone);
- determining binding globulin sex steroids (SHBG);
- biochemical blood;
The study of bone mineral density for the detection of osteoporosis, as well as a number of other necessary medical attention for making the diagnosis and research.
To date, the main role in the treatment of age- androgen deficiency assigned to testosterone replacement therapy in various forms. There are details on the application of supportive therapy chorionic gonadotropin (hCG), which aims at strengthening the synthesis of testosterone.
Modes of administration of testosterone preparations:
- transdermal or percutaneous (plasters, creams and gels);
- subcutaneous (testosterone implants);
- oral administration (capsules for oral administration);
- injection (oily solution for intramuscular injection).
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