The age of testosterone deficiency in men

Androgen deficiency in men.  Collage from the site

Age-related androgenic deficit— Is the lack of androgens (male sex hormone) in the male body that is associated with its natural aging. It is usually develops after age 50, but the first manifestations may occur much earlier — in40-45 years. It is accompanied by symptoms of androgen deficiency, affecting all organs and systems. At the heart androgenic Deficit reduction is the main production of male sex hormone testosterone.


Before talking about the causes of age-related androgen deficiency, it is necessary to say about where and how the formation of testosterone.

Testosterone — is main male hormone, the body responsible for:

  • growth and development of the genital organs;
  • the appearance of secondary sexual characteristics (hair growth on the face, trunk);
  • development muscle;
  • the formation of male behavior (proactivity, aggressiveness, etc.);
  • libido;
  • erection;
  • ability to produce sperm (spermatogenesis);
  • features of the distribution of adipose tissue;
  • development and structure of the skeleton.

Testosterone produced by Leydig cells in the testes under the influence of hormones produced in the central nervous system, pituitary gland and hypothalamus. These processes are dependent of each other and able to have complex mechanisms of regulation.

Among other things, he testosterone in the blood can be in several variants, or so-called fractions. Active fractions were isolated and inactive Testosterone. For the main effects of testosterone (see above) corresponds to the active testosterone.

There are many theories of aging, leading to the development of age-related androgen deficiency. The main reasons leading to the failure of testosterone are:

  • age-related changes in the testes (testicles), accompanied by a decrease in Leydig cells. They are associated with the development of atherosclerosis, reducing blood flow and nutrition of these cells, as well as to "program" the death of these cells (apoptosis);
  • age-related changes in the pituitary and hypothalamus, resulting in disturbed regulation of testosterone;
  • some genetic predisposition associated with the response of cells to testosterone and some pituitary and hypothalamus.

What way?

The main complaint, causing the man to turn todoctor andrology, is the weakening and disappearance of spontaneous or adequate erection, the extinction of sexual arousal, decreased frequency of sexual fantasies and libido. In addition to sexual dysfunction arises hot flashes, sweating, there is fatigue, irritability. Many men say the emergence of forgetfulness, sleep disorders, as well as a decrease in the ability to prolonged concentration.

There have been changes in the skin andMusculoskeletal System as wrinkles, hair loss, dryness and sagging skin, reduction of muscle mass and fat deposition appearance, gynecomastia (an increase mammary glands) of osteoporosis.


For the diagnosis of age-related androgen deficiency must be glad to laboratory tests:

  • study of different factions of testosterone (total testosterone, biologically active testosterone);
  • determining binding globulin sex steroids (SHBG);
  • biochemical blood;
  • CBC.

The study of bone mineral density for the detection of osteoporosis, as well as a number of other necessary medical attention for making the diagnosis and research.


To date, the main role in the treatment of age- androgen deficiency assigned to testosterone replacement therapy in various forms. There are details on the application of supportive therapy chorionic gonadotropin (hCG), which aims at strengthening the synthesis of testosterone.

Modes of administration of testosterone preparations:

  • transdermal or percutaneous (plasters, creams and gels);
  • subcutaneous (testosterone implants);
  • oral administration (capsules for oral administration);
  • injection (oily solution for intramuscular injection).

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